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Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse

✍ Scribed by Ella W. Yeung; Nicholas P. Whitehead; Thomas M. Suchyna; Philip A. Gottlieb; Frederick Sachs; David G. Allen

Book ID
110113070
Publisher
Cambridge University Press
Year
2005
Tongue
English
Weight
390 KB
Volume
562
Category
Article
ISSN
0022-3751

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The alpha 1 subunit of the L-type Ca2+ channel plays a dual role in skeletal muscle. It is essential both for L-type Ca2+ channel activity and for the functioning of the voltage-sensor structure that is situated in the triads as a key element for excitation-contraction coupling. This paper shows, wi