๐”– Bobbio Scriptorium
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Effects of stimulants on rotarod performance of mice

โœ Scribed by N. Plotnikoff; D. Reinke; J. Fitzloff


Publisher
John Wiley and Sons
Year
1962
Tongue
English
Weight
156 KB
Volume
51
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


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The amphetamine isomers impair the rotarod performance of rats in a dose-related manner, with (+)-amphetamine approximately four-times as potent as its (-)-isomer. At a rotation speed of 4 rpm, 60 min after i.p. administration, the TD50 values (mg/kg) were: (+)-amphetamine, 24 (21.9-26.4) and (-)-am

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Acute administration of d-amphetamine sulfate (30 mg/kg, i.p.) caused muscle weakness and 80 % failure in rotarod performance in rats, The incidence of performance failure progressively decreased to 30 % in animals receiving d-amphetamine and tested daily for 8 days. A similar progressive reduction