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Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages

✍ Scribed by Hisashi Matsuda; Tadashi Kageura; Toshio Morikawa; Iwao Toguchida; Shoichi Harima; Masayuki Yoshikawa

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 151 KB
Volume: 10
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(99)00702-7

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✦ Synopsis

AbstractÐTwo new anthraquinone glucosides [chrysophanol 8-O-b-d-(6 H -galloyl)-glucopyranoside, aloe-emodin 1-O-b-d-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-b-d-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2 HH -O-gallate, rhaponticin 6 HH -Ogallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages. (IC 50 =11±69 mM). The oxygen functions (-OH,-OCH 3 ) at

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