✦ LIBER ✦

Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease

✍ Scribed by Maaike Bakker; Rianne A.J. Esselink; Marten Munneke; Patricia Limousin-Dowsey; Hans D. Speelman; Bastiaan R. Bloem

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 108 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20116

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta‐analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase. © 2004 Movement Disorder Society

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