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Effects of caffeine on the freezing of gait in Parkinson's disease

✍ Scribed by Mayumi Kitagawa; Hideki Houzen; Kunio Tashiro

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
54 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Caffeine is a nonselective competitive blockade of adenosine A1 and A2A receptors. In this report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for patients with Parkinson's disease. Different subtypes of FOG showed different therapeutic responses to caffeine. Caffeine improved β€œtotal akinesia” type of FOG, but had no effect on β€œtrembling in place.” Tolerance developed to the beneficial effect of caffeine on FOG within a few months, but a 2‐week caffeine withdrawal period could restore the effect of caffeine. Β© 2007 Movement Disorder Society

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