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Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial

✍ Scribed by Jacques Gardon; Michel Boussinesq; Joseph Kamgno; Nathælie Gardon-Wendel; Demanga-Ngangue; Brian OL Duke

Book ID
117281171
Publisher
The Lancet
Year
2002
Tongue
English
Weight
288 KB
Volume
360
Category
Article
ISSN
0140-6736

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The effects of high-dose ivermectin regi
The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients
✍ Kwablah Awadzi; Simon Kwaku Attah; Ebenezer Thomas Addy; Nicholas Obuobisa Opoku 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 630 KB

Ivermectin, at the standard dose of 150 cLg/kg bodyweight, does not kill the adult worms of Onchocerca volvulus and does not disrupt embryogenesis or spermatogenesis. Repeated standard doses, if maintained, arrest microfilarial production but result in only a mild-to-modest macrofilaricidal effect.