Effects of spinal naloxone and naltrindole on the antinociceptive action of intrathecally administered dexmedetomidine
โ Scribed by Yoshito Takano; Manami Takano; Isao Sato; Tony L. Yaksh
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 362 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0913-8668
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The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine
We have previously described the paradoxical antinociceptive effect of low doses of an opiate antagonist, naloxone, in rats suffering from chronic arthritis induced by Freund's adjuvant. In the present work, the appearance of this naloxone sensitivity was studied, using a model of inflammatory hyper