𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of some monocyclic aromatic solvents and their metabolites on brain dopamine in rabbits

✍ Scribed by Alessandro Romanelli; Maurizio Fatzol; Anomio Mutti; Enrico Bergamaschi; Innocente Franchini

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
494 KB
Volume
6
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Adult male rabbits were exposed to high concentrations (750 ppm, 12 hours daily for 7 days) of toluene, xylenes, styrene, ethylbenzene, vinyltoluene (3-methylstyrene), and 7-methyl-styrene vapours or were dosed with 4 mM/kg/day i.p. of hippuric, methylhippuric, mandelic, phenylglyoxylic, and 7-methyl-mandelic acids. Styrene, vinyltoluene and ethylbenzene caused a marked depletion of striatal and tuberoinfundibular dopamine. Such an effect was also caused by treatment with phenylglyoxylic and mandelic acids. Dopamine depletion was associated with an increase in homovanillic acid concentration in the same regions. These results indicate that dopamine metabolism is a target for the neurotoxic effects of some monocyclic aromatic hydrocarbons and their metabolites, a lateral vinyl- or ethyl-chain being crucial for the structure/activity relationship of such compounds.

📜 SIMILAR VOLUMES

Effects of some β-carbolines on the conc
Effects of some β-carbolines on the concentrations of 5-hydroxytryptamine, dopamine, and some related metabolites in the cerebral ganglia of the cockroach (Periplaneta americana)
✍ Sloley, B. Duff 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB

The effects of the p-carbolines, harmaline, harmalol, harmane, and harmine on 5-hydroxytryptamine, dopamine, and tryptophan concentrations in the cerebral ganglion of the cockroach (Periplanela americana) were investigated. Injections of harmaline and harmine-induced decreases in the concentrations

The influence of some steric and electro
The influence of some steric and electron effects on the mechanism of aromatic nucleophilic substitution (SNAr) reactions in nonpolar solvent
✍ Thomas A. Emokpae; Nkechi V. Atasie 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

## Abstract Kinetic studies are reported for the reactions with aniline in benzene of a series of X‐phenyl 2,4,6‐trinitrophenyl ethers [X = H; 2‐, 3‐, 4‐CH~3~; 2,4‐, or 2,6‐(CH~3~)~2~] a–f, and the results compared with those of the corresponding nitro derivatives. In the methyl series, kinetic dat