✦ LIBER ✦

Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance

✍ Scribed by Michael W. Jann; Stephen R. Saklad; Larry Ereshefsky; Ann L. Richards; Charles A. Harrington; Chester M. Davis

Publisher: Springer
Year: 1986
Tongue: English
Weight: 309 KB
Volume: 90
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00174062

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✦ Synopsis

Plasma concentrations of haloperidol and its reduced metabolite (reduced haloperidol) were investigated in cigarette smokers (N = 23) and nonsmokers (N = 27). Steady-state plasma concentrations were obtained 12 h post bedtime dose. Haloperidol and reduced haloperidol concentrations were determined by RIA. Reduced haloperidol was separated by selective succinylation and liquid chromatography. Patients were clinically assessed with the Clinical Global Impression Scale (CGIS). Smokers had significantly lower haloperidol and reduced haloperidol plasma concentrations than nonsmokers (P less than 0.01, P less than 0.05). Clearance of haloperidol was significantly greater in smokers compared to nonsmokers (P = 0.0052). CGIS assessments did not show significant differences between smokers and nonsmokers. Plasma concentrations should be carefully monitored when patients either start or stop smoking.

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