Pharmacokinetics of haloperidol and reduced haloperidol in chinese schizophrenic patients after intravenous and oral administration of haloperidol
โ Scribed by Wen-Ho Chang; Y. W. Francis Lam; Michael W. Jann; Hong Chen
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 616 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Fifteen chinese schizophrenic patients were given titrated doses of haloperidol (0.05โ0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 ยฑ 4.8 ng/ml
A single dose of haloperidol decanoate 100 mg was administered to 15 schizophrenic patients. Blood samples were obtained prior to injection, 1 h, 3 h, 6 h,'8 h, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, one week, two weeks, three weeks and four weeks post-injection. Haloperidol and its reduced
Striatal homovanillic acid (HVA) levels and drug concentrations in striatum and plasma were examined in guinea pigs after acute and subchronic administrations of haloperidol (HAL) and reduced HAL (RHAL). HVA and drug levels were measured by high performance liquid chromatography with electrochemical