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Effects of single and multiple increasing doses of vigabatrin on brain gaba metabolism and correlation with vigabatrin plasma concentration

✍ Scribed by Elsa M. Valdizán; Juan A. Armijo

Book ID
115782681
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
968 KB
Volume
43
Category
Article
ISSN
0006-2952

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Effects of single doses of vigabatrin on
Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy
✍ Elinor Ben Menachem; Lennart I. Persson; Paul J. Schechter; Klaus D. Haegele; No 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 615 KB

Vigabatrin, as a single oral dose of 50 mg/kg, was administered to 11 patients with drug-refractory complex partial epilepsy. Serial lumbar punctures were performed prior to and 5 times within the first week following treatment. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homo