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Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures

✍ Scribed by Ognen A. C. Petroff; Fahmeed Hyder; Theresa Collins; Richard H. Mattson; Douglas L. Rothman

Book ID
109106827
Publisher
Wiley (Blackwell Publishing)
Year
1999
Tongue
English
Weight
756 KB
Volume
40
Category
Article
ISSN
0013-9580

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Effects of single doses of vigabatrin on
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Vigabatrin, as a single oral dose of 50 mg/kg, was administered to 11 patients with drug-refractory complex partial epilepsy. Serial lumbar punctures were performed prior to and 5 times within the first week following treatment. Cerebrospinal fluid (CSF) concentrations of total GABA, free GABA, homo

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