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Effects of silencing connective tissue growth factor (CTGF) by RNA interference on expression of matrix metalloproteinase-1 and -2 in human osteoblasts

✍ Scribed by Yiqun Peng; Guoliang Sui; Eryuan Liao

Book ID: 116320926
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 47 KB
Volume: 43
Category: Article
ISSN: 8756-3282
DOI: 10.1016/j.bone.2008.08.013

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## Abstract Connective tissue growth factor (CTGF/CCN2) is a matricellular protein induced by transforming growth factor (TGF)‐β and intimately involved with tissue repair and overexpressed in various fibrotic conditions. We previously showed that keratinocytes in vitro downregulate TGF‐β‐induced e