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Effects of scopolamine on immediate postural changes in heart rate and R—R variance in humans

✍ Scribed by Vikram K. Yeragani; Robert Pohl; Richard Balon; C. Ramesh; Richard Berchou

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
587 KB
Volume
7
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To examine the anticholinergic effects of scopolamine, postural tests were performed in nine healthy male volunteers after they received intravenous infusions of 0.2mg of scopolamine, 0.4 mg of glycopyrrolate, or placebo on separate days under double‐blind randomized conditions. Compared to the placebo and glycopyrrolate conditions, scopolamine produced a significantly exaggerated HR response to standing from supine posture. Scopolamine also produced a significant increase in R‐R variance during supine deep breathing and standing conditions as compared to glycopyrrolate and placebo conditions. At the same time, scopolamine also produced a significant dry mouth. These findings suggest that the effects of scopolamine in low doses on the above cardiac variables are vagomimetic.

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