✦ LIBER ✦

Effects of sciatic nerve stimulation on ACTH secretion, in intact and in variously hypothalamic deafferentated male rats

✍ Scribed by S. Feldman; N. Conforti; I. Chowers; R. A. Siegel

Publisher: Springer-Verlag
Year: 1981
Tongue: English
Weight: 281 KB
Volume: 42-42
Category: Article
ISSN: 0014-4819
DOI: 10.1007/bf00237514

No coin nor oath required. For personal study only.

✦ Synopsis

Serum ACTH levels were determined by RIA following sciatic nerve stimulation, in intact rats and in rats bearing anterior (AHD), posterior (PHD) or complete (CHD) hypothalamic deafferentations. In both N and PHD groups, serum ACTH concentrations were markedly elevated following stimulation. In CHD animals this response was completely eliminated, and in the AHD group only a very slight and marginally significant increase in serum ACTH occurred, upon stimulation. These results demonstrate that the increased corticosterone secretion which occurs following sciatic nerve stimulation is due to elevated blood levels of ACTH, and confirm that this somatosensory stimulation impinges upon the hypothalamus from the rostral directions.

📜 SIMILAR VOLUMES

ACTH and corticosterone secretion follow

ACTH and corticosterone secretion following insulin in intact and in variously hypothalamic deafferentated male rats

✍ J. Weidenfeld; R. A. Siegel; S. Feldman; N. Conforti; I. Chowers 📂 Article 📅 1982 🏛 Springer-Verlag 🌐 English ⚖ 332 KB

Adult male rats, intact (N) or with posterior (PHD), anterior (AHD) or complete (CHD) hypothalamic deafferentations, were injected with either 0.04 or 0.2 mu/100 g b.wt. of insulin. Forty-five minutes later they were decapitated and trunk blood was collected for serum glucose, adrenocorticotropic ho

Effect of interleukin-1 on adrenocortica

Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferentated male rats

✍ H. Ovadia; O. Abramsky; V. Barak; N. Conforti; D. Saphier; J. Weidenfeld 📂 Article 📅 1989 🏛 Springer-Verlag 🌐 English ⚖ 333 KB

The present study was designed to elucidate the site of action of interleukin 1 (IL-1) modulation of the hypothalamic-hypophyseal-adrenal (HHA) axis. An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS). In rats w

Effect of a calcium channel blocker on p

Effect of a calcium channel blocker on pituitary luteinizing hormone secretion in intact and castrated male and female rats

✍ V. N. Babichev; L. N. Sidneva; L. Yu. Ozol' 📂 Article 📅 1987 🏛 Springer US 🌐 English ⚖ 269 KB

Aldose reductase inhibition with imirest

Aldose reductase inhibition with imirestat — effects on impulse conduction and insulin-stimulation of Na+/K+-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats

✍ A. L. Carrington; C. B. Ettlinger; N. A. Calcutt; D. R. Tomlinson 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 633 KB

This study describes reduced motor nerve conduction velocity and increased resistance to hypoxia-induced conduction failure in sciatic nerves of rats after four weeks of streptozotocin-induced diabetes (both effects were significant at p < 0.05). These changes occurred in the absence of any deficit