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Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferentated male rats

✍ Scribed by H. Ovadia; O. Abramsky; V. Barak; N. Conforti; D. Saphier; J. Weidenfeld

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
333 KB
Volume
76
Category
Article
ISSN
0014-4819

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✦ Synopsis

The present study was designed to elucidate the site of action of interleukin 1 (IL-1) modulation of the hypothalamic-hypophyseal-adrenal (HHA) axis. An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS). In rats with complete mediobasal hypothalamic deafferentation, the HHA response to IL-1 was inhibited. An intracerebroventricular injection of rIL-1 (2 U/rat) caused a marked increase in serum ACTH and CS. These results suggest that IL-1 activates the HHA axis by a direct effect upon the brain, and that intact neural connections between the mediobasal hypothalamus and extrahypothalamic brain regions are essential for IL-1-induced HHA responses.

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