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Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain

✍ Scribed by Nora D. Volkow; Gene.-Jack Wang; Marian W. Fischman; Richard Foltin; Joanna S. Fowler; Dinko Franceschi; Maja Franceschi; Jean Logan; Samuel J. Gatley; Christopher Wong; Yu-Shin Ding; Robert Hitzemann; Naomi Pappas


Book ID
117172483
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
424 KB
Volume
67
Category
Article
ISSN
0024-3205

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Dopamine transporter (DAT) mRNA from selected brain regions of individual male Fischer rats was quantitated utilizing a sensitive solution hybridization assay in which the levels of RNase-protected 32 P-labeled mRNA:cRNA hybrids were measured. DAT mRNA was detected in whole brain regions known to co