Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration
β Scribed by Ana Hitri; Karley Y. Little; Everett H. Ellinwood Jr.
- Book ID
- 113387830
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 649 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1470-634X
No coin nor oath required. For personal study only.
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## Goeders, N.E.: The effects of chronic cocaine administration on brain neurotransmitter receptors. Drug Dev. Res. 20:349-357, 1990. The nonmedical use of cocaine has continued to increase during the past decade, resulting in considerable interest in the clinical and neurobiological implications
The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D 2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthan