The effects of a salicylate, ibuprofen,
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T. S. Tracy; K. Krohn; D. R. Jones; J. D. Bradley; S. D. Hall; D. C. Brater
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Article
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1992
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Springer
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English
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We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all th