Pharmacokinetics and pharmacodynamics of
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Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes
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Article
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1993
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John Wiley and Sons
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English
β 555 KB
In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,