Effects of Psychopharmacologic Agents on Experimentally-Induced Seizures in Mice**Received August 21, 1959, from the Departments of Pharmacology, University of Utah, College of Pharmacy and College of Medicine, Salt Lake City.

✍ Scribed by Fink, Gregory B. ;Swinyard, Ewart A.

• Publisher: Elsevier
• Year: 1960
• Weight: 384 KB
• Volume: 49
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030490807

✦ Synopsis

Of seven psychopharmacologic drugs screened by live assay procedures, only meprobamate and phenaglycodol exhibited significant anticonvulsant activity. Chlorpromazine, promazine, reserpine, and hydroxyzine lowered the threshold for minimal seizures variously induced, whereas t d u p r o m a z i n e had no effect on seizure threshold. The data obtained correlate well with available clinical data and indicate the value of threshold seizure studies in animals for detecting agents which may cause convulsions i n man.