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Effects of Propargylic Substitution and Annelation on the Cycloaromatization of a Bicyclo[7.3.1] Enediyne

✍ Scribed by Moss, David K.; Spence, John D.; Nantz, Michael H.

Book ID
126833105
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
65 KB
Volume
64
Category
Article
ISSN
0022-3263

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## Abstract Bicyclo[7.3.1]diynes 19a and 19b were prepared by using dibromo olefin 11 and ketone 12 as building blocks. The key step of the synthetic sequence is an intramolecular Nicholas reaction of 17 to give the bicyclo[7.3.1]diyn‐10‐one dicobalthexacarbonyl adducts 18a and 18b (66% total yield