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Effects of Proglumide on Morphine Analgesia and Tolerance

โœ Scribed by LUCIO C. ROVATI; PAOLA SACERDOTE; ALBERTO E. PANERAI

Book ID
118722657
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
116 KB
Volume
448
Category
Article
ISSN
0890-6564

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Proglumide (0.02 mg/kg), a cholecystokinin antagonist, was administered to rats either together with or without morphine (0, 5, 15, or 45 mg/kg). Whereas proglumide in the absence of morphine showed a trend towards enhanced behavioral activation, it potentiated the hypokinesia induced by morphine. T