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Effects of Pro → Peptoid Residue Substitution on Cell Selectivity and Mechanism of Antibacterial Action of Tritrpticin-Amide Antimicrobial Peptide †

✍ Scribed by Zhu, Wan Long; Lan, Hongliang; Park, Yoonkyung; Yang, Sung-Tae; Kim, Jae Il; Park, Il-Seon; You, Ho Jin; Lee, Jung Sup; Park, Yong Sun; Kim, Yangmee; Hahm, Kyung-Soo; Shin, Song Yub


Book ID
126999172
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
300 KB
Volume
45
Category
Article
ISSN
0006-2960

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Effects of dimerization of the cell-pene
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## Abstract The cell‐penetrating peptide Tat (48–60) (GRKKRRQRRRPPQ) derived from HIV‐1 Tat protein showed potent antibacterial activity (MIC: 2–8 µM). To investigate the effect of dimerization of Tat (48–60) analog, [Tat(W): GRKKRRQRRRPWQ‐NH~2~], on antimicrobial activity and mechanism of bacteric