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Effects of potential inhibitors on metabolism of griseofulvin in vitro

โœ Scribed by S. A. Kaplan; S. Riegelman; K. H. Lee

Publisher
John Wiley and Sons
Year
1966
Tongue
English
Weight
509 KB
Volume
55
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The inhibitory effects of p-ethoxyacetanilide, p-methoxybenzylamine, codeine, and SK&F 525-A on the metabolism of griseofulvin were studied in a Krebs-Ringer bicarbonate liver-slice system. This investigation sought to determine the possibility of prolonging the biological activity of griseofulvin.

RISEOFULVIN, the first available oral antifrom the mycelium of Penicillium griseofuloum by G fungal antibiotic, was originally isolated Oxford in 1939 (1). However, it was not until 1958 that Gentles (2) reported that he was abk to eradicate experimental ringworm of guinea pigs as a result of oral treatment with griseofulvin.

(3, 41, Blank et az. (5), and Williams (61, who obtained favorable results in the treatment of superficial fungi infections of man.

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