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Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1

✍ Scribed by Tomohiro Nabekura; Takeshi Yamaki; Kazuyuki Ueno; Shuji Kitagawa


Book ID
116296431
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
299 KB
Volume
369
Category
Article
ISSN
0006-291X

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The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined