Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat
β Scribed by Adaline C. Smith; Stephen M. Roberts; Lawrence M. Berman; Raymond D. Harbison; Robert C. James
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 653 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0300-483X
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Although the depletion of hepatic glutathione in male rats following treatment with phorone (diisopropylidene acetone) did not affect the xenobiotic-metabolizing microsomal enzyme system, the metabolic elimination of vinylidene chloride (VDC) from the atmosphere of a closed exposure system was inhib
## Abstract Hepatotoxicity of vinylidene chloride (1,1βdichloroethylene, VDC) in rats was evidenced by increases of serum enzyme activities of the aminotransferases (GOT, GPT) and sorbitol dehydrogenase (SDH). Simultaneous treatment with ethanol (4.8 g kg^β1^ p.o.) totally inhibited these hepatotox