Influence of alcohol, dithiocarb and (+)-catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats

✍ Scribed by C.-P. Siegers; K. Heidbüchel; M. Younes

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 556 KB
• Volume: 3
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550030208

✦ Synopsis

Abstract

Hepatotoxicity of vinylidene chloride (1,1‐dichloroethylene, VDC) in rats was evidenced by increases of serum enzyme activities of the aminotransferases (GOT, GPT) and sorbitol dehydrogenase (SDH). Simultaneous treatment with ethanol (4.8 g kg^−1^ p.o.) totally inhibited these hepatotoxic effects, whereas pretreatment with the same ethanol dose 24h prior to VDC had no effect. Dithiocarb or (+)‐catechin (0.2 g kg^−1^;p.o.), administered simultaneously with VDC, significantly reduced the VDC‐induced increments of serum enzyme activities. Pretreatment with 5% ethanol for 7 days instead of drinking water increased the hepatotoxicity of a single dose of VDC. The combined treatment with VDC (0.125–0.2 g kg^−1^, twice weekly) and 5% ethanol for 4 weeks led to only small increases of serum enzyme activities as compared with controls treated with VDC alone. However, 60% lethality occurred in the VDC‐ethanol group. Administration of either dithiocarb or (+)‐catechin with VDC totally antagonized the observed lethality. Metabolic studies with VDC in a closed exposure system indicated that simultaneous treatment with ethanol or dithiocarb totally depressed the metabolic removal of VDC, whereas (+)‐catechin had no effect.