Effects of phthalic acid esters on drug
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R. Gollamudi; W. H. Lawrence; R. H. Rao; J. Autian
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Article
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1985
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John Wiley and Sons
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English
β 372 KB
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Di(2-ethylhexyl)phthalate (DEHP) inhibited UDP-glucuronyltransferase activity of rat liver in vitro and in vivo. Diethyl phthalate and dimethoxyethyl phthalate also inhibited this enzyme in vitro. On the other hand, DEHP did not inhibit the activity of the cytosolic enzyme N-acetyltransferase; it al