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Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea

✍ Scribed by Shikada Ken-ichi; Yamamoto Akiko; Tanaka Sakuya

Book ID
115886981
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
655 KB
Volume
195
Category
Article
ISSN
0014-2999

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro