Effects of phentermine and cocaine on fenfluramine-induced depletion of serotonin in mouse brain
โ Scribed by Michael H. Baumann; Charles R. Schuster; Richard B. Rothman
- Book ID
- 116130785
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 398 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0376-8716
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Until recently, (ฯฎ)fenfluramine (FEN) was widely prescribed as an appetite suppressant. In animals, FEN is a potent and selective brain serotonin neurotoxin. The present studies assessed the effects of phentermine (PHEN), an appetite suppressant frequently used clinically in combination with FEN, on
Various effects of chlorpheniramine (CPA), diphenhydramine (DIPH), tripelennamine (TRIP), and pyrilamine (PYRI) on fenfluramine (FEN)-induced depletion of serotonin in the brain of rats were observed to be dependent on body temperature. Levels of 5-HT and 5-HIAA in the frontal cortex, hippocampus, a
Combined administration of the amphetamine analogs phentermine and fenfluramine (PHEN/FEN) has been used in the treatment of obesity. While these medications are thought to modulate monoamine transmission, the precise neurochemical effects of the PHEN/FEN mixture have not been extensively studied. T