Effects of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in rats
โ Scribed by Joseph F. Williams; Saul Lowitt; Andor Szentivanyi
- Book ID
- 115774808
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 692 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0006-2952
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The effects of pretreatment with the enzyme inducers, phenobarbital (PB) and 3-methylcholanthrene (3-MC), on the pharmacokinetic and pharmacodynamic parameters of bumetanide were examined in rats. The nonrenal clearance (19.3 vs 29.6 ml min-' per kg) of bumetanide increased significantly in PB treat
The eects of pretreatment with the enzyme inducers phenobarbital (PB) and 3methylcholanthrene (3-MC) and the enzyme inhibitor chloramphenicol (CM) on the pharmacokinetic and pharmacodynamic parameters of azosemide were examined after intravenous (IV) administration of azosemide, 10 mg kg 71 , to rat