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Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain

✍ Scribed by Stacey Carmody; Lorraine Brennan


Book ID
116765390
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
492 KB
Volume
56
Category
Article
ISSN
0197-0186

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The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mgikg) and UK 38,485 (50 mgikg). Both compounds selectively decreased ( > 90%) TXB2 production in brain measured after 2 min of con