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Effects of Paracetamol on the Pharmacokinetics of Ciprofloxacin in Plasma Using a Microbiological Assay

✍ Scribed by Mahmoud Mohamed Issa, Dr R’afat Mahmoud Nejem, Naser Said El-Abadla, Mohamed Khamis El-Naby, Abeer Ahmed Roshdy, Zainab Assan Kheiralla


Book ID
119930186
Publisher
Springer International Publishing AG
Year
2007
Tongue
English
Weight
97 KB
Volume
27
Category
Article
ISSN
1179-1918

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Plasma and urine concentrations of codeine and its measurable metabolites were determined by HPLC in six healthy subjects after a single 30 mg oral dose of codeine either alone or after 7 doses of 1 g paracetamol 8 hourly. After codeine alone, the t1/2 (h), AUC (mumol.l-1.h) and CLR (ml.min-1) for c