Effects of pantothenic acid-deficient diets in patients with carcinomas

✍ Scribed by Arthur G. Ship; William E. Schal'Ten; Donald M. Watkin; Marjorie Romine

• Book ID: 101321476
• Publisher: John Wiley and Sons
• Year: 1958
• Tongue: English
• Weight: 467 KB
• Volume: 11
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(195809/10)11:5<933::aid-cncr2820110509>3.0.co;2-v

✦ Synopsis

HE PRODUCXION of oncolysis by the admin-T istration of adenoidal-pharyngeal-conjunctival (APC) viruses to patients with carcinoma of the cervix has been limited." The cessation of oncolysis by the adenoviruses appears to be related to the rise in antibody titers that occurs within 5 to 7 days after virus is inoculated into tumor.

Axelrod and Pruzansky,* Zucker a n d Zucker,17 and Serondela have demonstrated an inhibition of antibody response in pantothenic acid-deficient rats. Bean et al.* have suggested that the production of pantothenic acid-deficient states in patients might interfere with adequate synthesis of antibodies. Regression of tumor growth in animals following temporary induction of pantothenic acid deficiency has also been reported.8

The experimental evidence suggesting the possibility of altering antibody formation and tumor growth by inducing a pantothenic aciddeficient state prompted a study of the effects of pantothenic acid-deficient diets in patients with carcinomas.

Methods

Five patients, ranging in age from 48 to 63