It can be postulated that among the factors implicated in cartilaginous lesions, oxygen-derived free radicals seem to have a prominent part. To investigate this hypothesis, rabbit articular chondrocyte cultures have been exposed to oxygenderived reactive species generated by the hypoxanthine-xanthin
✦ LIBER ✦
Effects of oxygen free radicals on articular chondrocytes in culture: C-myc and c-Ha-ras messenger RNAs and proliferation kinetics
✍ Scribed by Françoise Vincent; Marisol Corral; Nicole Defer; Monique Adolphe
- Book ID
- 115892546
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 992 KB
- Volume
- 192
- Category
- Article
- ISSN
- 0014-4827
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## Abstract We have characterized the effect of the hepatomitogen epidermal growth factor (EGF) on the expression of the cellular protooncogenes c‐Ha‐ras and c‐myc in short‐term (48 hours) primary hepatocyte culture. mRNA concentrations of both protooncogenes increased dramatically in nonproliferat