𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effects of nitrogen and alkene substitution on the PtCl2 catalyzed cycloisomerization of N-tethered 1,6-enyne precursors to the triple reuptake inhibitor GSK1360707

✍ Scribed by Vassil Elitzin; Bing Liu; Matthew Sharp; Elie Tabet

Book ID
104099255
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
376 KB
Volume
52
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

I) catalysis

Nitrogen substitution effect Alkene substitution effect a b s t r a c t

The effects of nitrogen and alkene substitution on the cycloisomerization of N-tethered 1,6-enynes into 3azabicyclo[4.1.0]heptene precursors to the triple reuptake inhibitor GSK1360707 are described. In general, electron donating substituents proved beneficial both in terms of the reaction rate and chemoselectivity.

📜 SIMILAR VOLUMES

ChemInform Abstract: Effects of Nitrogen
ChemInform Abstract: Effects of Nitrogen and Alkene Substitution on the PtCl2-Catalyzed Cycloisomerization of N-Tethered 1,6-Enyne Precursors to the Triple Reuptake Inhibitor GSK1360707.
✍ Vassil Elitzin; Bing Liu; Matthew Sharp; Elie Tabet 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

## Abstract The more electron‐withdrawing the N‐protecting group and the alkene substituent, the slower is the reaction rate of the cycloisomerization of 1,6‐enynes to yield bicyclic products (II) and (IV).