✦ LIBER ✦
ChemInform Abstract: Effects of Nitrogen and Alkene Substitution on the PtCl2-Catalyzed Cycloisomerization of N-Tethered 1,6-Enyne Precursors to the Triple Reuptake Inhibitor GSK1360707.
✍ Scribed by Vassil Elitzin; Bing Liu; Matthew Sharp; Elie Tabet
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 34 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
The more electron‐withdrawing the N‐protecting group and the alkene substituent, the slower is the reaction rate of the cycloisomerization of 1,6‐enynes to yield bicyclic products (II) and (IV).