Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats
β Scribed by Daniel Keyler; Paul R Pentel; Gwendolyn Kuehl; Greg Collins; Sharon E Murphy
- Book ID
- 116332851
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 150 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0304-3835
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## Abstract ## BACKGROUND In the United States, Blacks who smoke cigarettes have a higher mean blood concentration of the nicotine metabolite cotinine than White smokers. It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4β(methylnitr
## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di