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Effects of NGF on the biosynthesis of chromogranin A and B, secretogranin II and carboxypeptidase H in rat PC12 cells

✍ Scribed by Laslop, A.; Tschernitz, C.

Book ID
122595484
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
126 KB
Volume
21
Category
Article
ISSN
0197-0186

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogen‐activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig