Effects of nerve growth factor and cAMP on expression of acetylcholine receptor in PC12 cells
โ Scribed by Furukawa, Katsutoshi; Sugimoto, Akira; Onodera, Hiroshi; Kogure, Kyuya; Akaike, Norio
- Book ID
- 123373963
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 255 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0168-0102
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## Abstract Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytom
Treatment of PC12 cells with dexamethasone leads, in a period of days, to a 60% decrease in the binding of (125I)nerve growth factor. The decrease was maximal after 3 days of treatment with 1 microM dexamethasone, but some decrease was seen after 6 hr and at concentrations as low as 10 nM. The effec