The effects of somatostatin (SRIF) and its long-acting analogue, SMS 201-995 on the prevention and treatment of acute pancreatitis were studied in rats. Acute pancreatitis was established by ligating the bile duct at the point of entry into the duodenum, thereby allowing reflux of bile into the panc
Effects of nafamostat mesilate, somatostatin, and glucagon on caerulein-induced acute pancreatitis in rats
โ Scribed by Mori, Kikuo ;Marugami, Yoshihisa ;Sakurai, Yoichi ;Ochiai, Masahiro ;Hasegawa, Shigeru ;Imazu, Hiroki ;Matsubara, Toshiki ;Suganuma, Masashi ;Shikata, Atsushi ;Funabiki, Takahiko
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 625 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0944-1166
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The secretion of somatostatin and glucagon by the perfused rat pancreatico-duodenal preparation was examined in situ under control conditions and after the induction of acute insulin deficiency by alloxan or streptozotocin. A 10 min 0.625 mmol/l alloxan perfusion resulted in an immediate and transie
The effects of the cholecystokinin (CCK)-analogue, caerulein, and CCKreceptor antagonist lorglumide (CR-1409) on pancreatic carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) were studied. One hundred thirty rats were divided into the following 10 treatment groups: group 1, DMBA (2-3 mg