✦ LIBER ✦

Effects of n-3 polyunsaturated fatty acids on endothelial function

✍ Scribed by John Stanley

Publisher: Wiley (John Wiley & Sons)
Year: 2007
Tongue: English
Weight: 282 KB
Volume: 19
Category: Article
ISSN: 0956-666X
DOI: 10.1002/lite.200600023

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Dysfunction of the vascular endothelium is an early event in the development of cardiovascular disease and methods are now available to measure endothelial function in vivo in man. Endothelial function may have advantages as an endpoint in human nutrition intervention trials over cardiovascular risk factors. Several studies have now been published on effects of the n‐3 polyunsaturated fatty acids on endothelial function. When ingested together, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have favourable effects on vasodilation in coronary arteries, brachial arteries and the skin microcirculation. However, published studies do not agree on the effects of EPA and DHA when ingested separately. Further research is needed to resolve these disagreements and extend these observations particularly at intakes of EPA and DHA which are achievable by diet.

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