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Effects of mutations of active site residues and amino acids interacting with the Ω loop on substrate activation of butyrylcholinesterase

✍ Scribed by Patrick Masson; Weihua Xie; Marie-Thérèse Froment; Oksana Lockridge


Book ID
114148879
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
309 KB
Volume
1544
Category
Article
ISSN
0167-4838

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✍ Setsuko Nakagawa; Hideaki Umeyama 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 370 KB

As part of a study of the catalytic mechanism of carboxypeptidase A, two proton transfers in the system Glu 270-H20-Zn-His 69-Asp 142 are treated with an ab initio MO method. Results show that the proton transfers are strongly affected by the environment. It is predicted that the proton between His