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Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes

✍ Scribed by Lois D Lehman-McKeeman; Douglas Caudill; Jeffrey D Vassallo; Robin E Pearce; Ajay Madan; Andrew Parkinson


Book ID
119540855
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
379 KB
Volume
111
Category
Article
ISSN
0378-4274

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Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX is also capable of inducing cytochrome P450 enzymes in a manner similar to that of phenobarbital (PB), which suggests that epigenetic mechani

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