Effects of MF-268, a new cholinesterase inhibitor, on acetylcholine and biogenic amines in rat cortex

✍ Scribed by X.-D. Zhu; G. Cuadra; M. Brufani; T. Maggi; P. G. Pagella; E. Williams; E. Giacobini

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 663 KB
• Volume: 43
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490430116

✦ Synopsis

MF-268 bitartrate [(3a S, 8a R)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol[8-(cis2,-6-dimethyl-morpholin-4-yl)octyl]-carbamate L-bitar- trate hydrate; Mediolanum Farmaceutici, Milan, Italy] is a pseudo-reversible carbamate-type cholinesterase inhibitor (ChEI) which interacts with the catalytic and regulatory anionic site of the enzyme. Its