Effects of metal ions on the structure and spectra of the peptide group

✍ Scribed by D. Balasubramanian; B. C. Misra

• Publisher: Wiley (John Wiley & Sons)
• Year: 1975
• Tongue: English
• Weight: 468 KB
• Volume: 14
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.1975.360140510

✦ Synopsis

Abstract

The interaction between salts of Groups IA and IIA and model aliphatic amides has been studied. The interaction has been monitored by calorimetry and spectroscopy. Among the alkali cations, lithium ion interacts strongest, while in Group II calcium appears to interact somewhat stronger than magnesium. The metal cation binds to the amide oxygen atom and causes alteration in the amide group geometry. As a consequence, significant alterations are seen in the infrared, nuclear magnetic resonance, ultraviolet, and circular dichroism spectra of the ligand peptide. These findings are suggested to be of importance to the conformational studies of polypeptides and proteins.