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Effects of Memantine on Latent Inhibition of Active Avoidance in Wistar Rats

✍ Scribed by L. V. Loskutova; N. V. Kostjunina

Publisher
Springer US
Year
2009
Tongue
English
Weight
168 KB
Volume
147
Category
Article
ISSN
0007-4888

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Rats trained to avoid electrical shock in a shuttle box were given phencyclidine (0.0, 1.0, 5.0, or 10.0 mg/kg) prior to testing for 5 consecutive days. There was a dose-dependent increase in both avoidance and escape failures although animals continued to cross the barrier during intertrial interva