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Effects of Macrocycle Size and Rigidity on Melanocortin Receptor-1 and -5 Selectivity in Cyclic Lactam α-Melanocyte-Stimulating Hormone Analogs

✍ Scribed by Alexander V. Mayorov; So-Yeop Han; Minying Cai; Matthew R. Hammer; Dev Trivedi; Victor J. Hruby


Book ID
111368298
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
113 KB
Volume
67
Category
Article
ISSN
1747-0277

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Analogs of α-melanocyte stimulating horm
✍ Maria A. Bednarek; Tanya MacNeil; Rui Tang; Tung M. Fong; M. Angeles Cabello; Ma 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 133 KB

## Abstract α‐Melanocyte stimulating hormone (αMSH), Ac‐Ser^1^‐Tyr^2^‐Ser^3^‐Met^4^‐Glu^5^‐His^6^‐Phe^7^‐Arg^8^‐Trp^9^‐Gly^10^‐Lys^11^‐Pro^12^‐Val^13^‐NH~2~, is an endogenous agonist for the melanocortin receptor 1 (MC1R), the receptor found in the skin, several types of immune cells, and other per