Effects of low dose total body irradiation (LDTBI) and recombinant human interleukin-2 in mice
β Scribed by Fourquet, A.; Teillaud, J.-L.; Lando, D.; Fridman, W.-H.
- Book ID
- 123123830
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 747 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0167-8140
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The aim of this work was to improve radiotherapy results by immune stimulation. We tested the effects of a combination of radio-and immunotherapy, i.e., local low dose recombinant interleukin-2 (rIL-2) treatment, in two murine tumor models. Syngeneic tumors (SL2 lymphoma or M8013 mammary carcinoma)
## Abstract Intraperitoneal (i. p.) treatment of MOPC104E ascitic tumorβbearing BALB/c mice with interleukinβ1 (ILβ1) followed by a low dose of cyclophosphamide (CPA) resulted in synergistic prolongation of their survival time. This antitumor effect was abolished when administration of CPA preceded